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MRT-68921 hydrochloride
CAS No. 2080306-21-2
MRT-68921 hydrochloride( MRT 68921 hydrochloride | MRT68921 hydrochloride )
Catalog No. M13240 CAS No. 2080306-21-2
MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 50 | In Stock |
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| 10MG | 85 | In Stock |
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| 25MG | 177 | In Stock |
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| 50MG | 321 | In Stock |
|
| 100MG | 420 | In Stock |
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| 200MG | 618 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMRT-68921 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionMRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
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DescriptionMRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively; inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK; reduces phospho-ATG13 and blocks autophagy in cells.
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In Vitro——
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In Vivo——
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SynonymsMRT 68921 hydrochloride | MRT68921 hydrochloride
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PathwayAutophagy
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TargetULK
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RecptorULK
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Research Area——
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Indication——
Chemical Information
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CAS Number2080306-21-2
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Formula Weight471.038
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Molecular FormulaC25H35ClN6O
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Purity>98% (HPLC)
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SolubilityH2O: 10 mg/mL
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SMILESCN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5.Cl.Cl
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Chemical NameCyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-,hydrochloride (1:2)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.
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